Name: PNC-27 30mg (10 Vials / Kit)
Brand: Uther Peptide
SKU: UP-PNC-27-30MG
Price: 270.00 USD
Availability: InStock

What is PNC-27?

PNC-27 links residues 12-26 of the p53 tumor-suppressor protein, the region that binds the regulatory protein HDM-2, to a membrane-residency peptide sequence. The design is intended to exploit a feature reported in many cancer cell lines: elevated HDM-2 expression on the outer cell membrane, which is largely absent from normal cells.

How it is understood to work

PNC-27 is reported to bind membrane-associated HDM-2 on cancer cells and, through its membrane-penetrating segment, form pores in the cell membrane that cause rapid cell lysis. Because this action is described as necrosis triggered at the membrane rather than classical apoptosis through intracellular p53 signaling, researchers study it as a mechanism distinct from typical p53-pathway reactivation strategies.

Research status

PNC-27 is studied almost exclusively in in-vitro oncology research, using cultured cancer cell lines to examine membrane-targeted cytotoxicity and selectivity relative to normal cells lacking membrane HDM-2. This work remains at the cell-culture stage; it has not been evaluated in controlled animal or human trials, so claims about anti-cancer efficacy are not established.

This listing: Uther Peptide PNC-27

Brand: Uther Peptide
Kit: 10 vials × 30 mg (300 mg in total)
Price per vial: $27.00
Price per mg: $0.90
Also sold by: TFC Peptides 10mg $150.00 · TFC Peptides 5mg $85.00 · HK Peptide 10mg $140.00

Lab testing

Uther Peptide published a Janoshik report for this compound. Test: Identity & purity. Result: PNC-27 30mg. Tested Sep 12, 2025.

View the report · How to read it (Testing 101) · Every report for this compound

Bought through escrow: the brand is only paid after you confirm delivery. If the parcel never arrives, or an independent test shows the wrong compound or a significant under-fill, open a claim before releasing payment.

Specifications

Compound: PNC-27
Class: p53-derived membrane-lytic peptide
Form: Lyophilized (freeze-dried) powder
Per vial: 30mg
Molecular formula: C₁₈₈H₂₉₃N₅₃O₄₄S
Molecular weight: 4031.7 g/mol
Stated purity: 99%

Handling & storage

Supplied as a lyophilized powder; store unopened vials at -20C protected from light, and keep reconstituted solution refrigerated, using it within the timeframe set by the study protocol.

Concentration check: adding 2 ml of bacteriostatic water to one 30 mg vial gives 15 mg/ml. The Research Lab calculator in your dashboard works this out for any volume.

Questions

How does PNC-27’s mechanism differ from other p53-related peptides?

Rather than restoring p53 activity inside the cell nucleus, PNC-27 is designed to act at the cell membrane, binding surface HDM-2 and physically disrupting the membrane, a distinct mode of action from intracellular p53-MDM2 pathway modulators.

Why is normal-cell selectivity reported for PNC-27?

Researchers report that normal cells largely lack membrane-surface HDM-2 expression, which is proposed as the basis for PNC-27’s selective activity in cancer cell models, though this selectivity has only been characterized in vitro.

How much PNC-27 is in this kit?

10 vials of 30 mg each, so 300 mg in total. The lab testing section above shows what the brand’s tested vial actually contained.

For laboratory research use only. Not for human or veterinary use. Nothing on this page is medical advice.